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Jacob Klein
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Message 53905 - Posted: 13 Mar 2020 | 13:20:47 UTC
Last modified: 13 Mar 2020 | 13:26:34 UTC

Hey community,

If you would like to contribute to an immediate need (especially while GPU work is dwindling at GPUGrid)...

I recommend installing Folding@home and setting it to work on "Any disease", which will allow your resources to be used for new COVID-19 Coronavirus tasks. They have spun up some GPU projects a few days ago, and even some CPU projects more recently. Links below.

The software is a bit clunky, but it is also relatively easy to set up. For the short term, I am allocating all my beefy GPUs resources toward working on Coronavirus, and about half of my CPU resources.

Note: I have a lot of passion for GPUGrid, and will definitely come back to it. I'm just recommending a temporary (few weeks/months?) switch, to help an immediate need.

https://foldingathome.org/

https://foldingathome.org/2020/03/10/covid19-update/

https://foldingforum.org/viewtopic.php?f=24&t=32287

https://www.facebook.com/permalink.php?story_fbid=2953361518064379&id=136059519794607

Thanks,
Jacob Klein

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Message 53922 - Posted: 15 Mar 2020 | 8:58:34 UTC
Last modified: 15 Mar 2020 | 8:59:06 UTC

Note: I have a lot of passion for GPUGrid, and will definitely come back to it. I'm just recommending a temporary (few weeks/months?) switch, to help an immediate need.


+1
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Message 53923 - Posted: 15 Mar 2020 | 11:58:14 UTC - in response to Message 53922.
Last modified: 15 Mar 2020 | 11:59:00 UTC

I am planning SARS-CoV-2 work.


(especially while GPU work is dwindling at GPUGrid


GPU work is NOT dwindling here.

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Message 53924 - Posted: 15 Mar 2020 | 14:23:58 UTC
Last modified: 15 Mar 2020 | 15:00:15 UTC

Excellent !!
Also, sorry for being wrong about GPUGrid work supply.

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Message 53925 - Posted: 15 Mar 2020 | 14:56:45 UTC - in response to Message 53923.

I am planning SARS-CoV-2 work.

Toni, Outstanding!!!
Count me in.

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Message 53929 - Posted: 16 Mar 2020 | 14:18:03 UTC - in response to Message 53923.

Excellent! Thanks for the update. Hope to get some of those SARS-CoV-2 work units soon!

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Message 53932 - Posted: 17 Mar 2020 | 13:58:26 UTC

Rosetta@home also has COVID-19 WUs (CPU only).

https://boinc.bakerlab.org/rosetta/forum_thread.php?id=13533
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Message 53933 - Posted: 17 Mar 2020 | 15:00:43 UTC

Toni
I have this WU- https://www.gpugrid.net/workunit.php?wuid=17678083 stuck since the outage, awaiting validation. Can anything set it free?
Thanks

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Message 53937 - Posted: 17 Mar 2020 | 20:40:05 UTC - in response to Message 53932.
Last modified: 17 Mar 2020 | 20:41:22 UTC

Rosetta@home also has COVID-19 WUs (CPU only).

https://boinc.bakerlab.org/rosetta/forum_thread.php?id=13533

Rosetta code is flawed in how it handles your L3 Cache. You need to budget 5 MB L3 Cache per Rosetta and MIP (WCG MIP uses Rosetta code).
<app_config>
<app>
<name>rosetta</name>
<!-- needs 5 MB L3 cache per WU -->
<!-- needs 1.5 GB RAM per WU -->
<!-- Xeon E5-2686 v4, 18c36t, 32 GB, 45 MB L3 Cache -->
<max_concurrent>9</max_concurrent>
</app>
<app>
<name>minirosetta</name>
<!-- needs 5 MB L3 cache per WU -->
<max_concurrent>1</max_concurrent>
</app>
<project_max_concurrent>9</project_max_concurrent>
</app_config>

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Message 53940 - Posted: 18 Mar 2020 | 7:59:49 UTC - in response to Message 53923.

I am planning SARS-CoV-2 work.

You better upgrade the server(s) before you do! FAH servers are overwhelmed.
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Message 53949 - Posted: 19 Mar 2020 | 1:47:36 UTC - in response to Message 53923.

Toni, will these work units be GPU, CPU, both? I know to some that may be a silly question but GPUGrid has dabbled with GPU, CPU, ARM (Android), and virtualbox in the past. Just wanted to know what to look forward to.
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Message 53955 - Posted: 20 Mar 2020 | 14:54:12 UTC - in response to Message 53932.

Rosetta@home also has COVID-19 WUs (CPU only).

https://boinc.bakerlab.org/rosetta/forum_thread.php?id=13533

Thank you, Chilean!

I've already joint to Rosetta@home, as it is a CPU only project and, therefore, complementary to GPUGrid

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Message 53956 - Posted: 21 Mar 2020 | 2:45:08 UTC - in response to Message 53940.

You better upgrade the server(s) before you do!


So goes the conundrum of distributed computing...

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Message 53957 - Posted: 21 Mar 2020 | 6:08:38 UTC - in response to Message 53955.

I've already joint to Rosetta@home, as it is a CPU only project and, therefore, complementary to GPUGrid

+ 1

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Message 53958 - Posted: 21 Mar 2020 | 10:19:49 UTC - in response to Message 53956.

You better upgrade the server(s) before you do!

So goes the conundrum of distributed computing...
The real conundrum is the preparedness of the public health services and/or governments which is put to the test by this world wide pandemic.

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Message 53959 - Posted: 21 Mar 2020 | 14:11:23 UTC - in response to Message 53958.

You better upgrade the server(s) before you do!

So goes the conundrum of distributed computing...
The real conundrum is the preparedness of the public health services and/or governments which is put to the test by this world wide pandemic.
Also:
1. The unsanitary food processing practices of China are antediluvian.
2. ImPOTUS has ravaged science in America and our response is many weeks behind where it should be. The US government fell on their face.

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Message 53960 - Posted: 21 Mar 2020 | 15:48:01 UTC
Last modified: 21 Mar 2020 | 15:49:37 UTC

Okay okay ....
:) Back to Crunching for Coronavirus! :)

Does anybody know of any cool methods to somehow have my GPUs crunch Folding@home if they have a work unit available to them, but if they don't (Since there are server outages there sometimes) automatically switch over to BOINC?

I have .bat files that can turn BOINC GPU Computing from GPU Suspended to Use GPU based on preferences ... but I guess I need to do more research into finding a way to detect Folding@Home slot fulfillment for my GPU devices.

I guess I'll be starting here:
https://github.com/FoldingAtHome/fah-control/wiki/3rd-party-FAHClient-API

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Message 53963 - Posted: 21 Mar 2020 | 19:27:19 UTC - in response to Message 53960.

As folding@home is in the media now with many new users and servers are already overloaded I would recommend to stay at Rosetta for CPU and GPUgrid for GPU.

I already tell that other new users of folding@home which cannot get enough work units yet.

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Message 53966 - Posted: 21 Mar 2020 | 20:01:59 UTC - in response to Message 53960.

Okay okay ....
:) Back to Crunching for Coronavirus! :)

Does anybody know of any cool methods to somehow have my GPUs crunch Folding@home if they have a work unit available to them, but if they don't (Since there are server outages there sometimes) automatically switch over to BOINC?

I have .bat files that can turn BOINC GPU Computing from GPU Suspended to Use GPU based on preferences ... but I guess I need to do more research into finding a way to detect Folding@Home slot fulfillment for my GPU devices.

I guess I'll be starting here:
https://github.com/FoldingAtHome/fah-control/wiki/3rd-party-FAHClient-API

If you were following the greatest BOINC team site in the world, which everyone should be ;) you'd know that all you need to do is set exclusions in cc_config for FahCore_21.exe and 22. This works for GPU, which is all that I'm doing.

<exclusive_app>FahCore_21.exe</exclusive_app>
<exclusive_app>FahCore_22.exe</exclusive_app>

Set your preferred project to a resource share of zero and you're good to go. I was using PrimeGrid for this at first because I wasn't expecting the FAH client to be out of work for hours at a time. The current GPUGrid work is fine for this, in fact I've run more GPUGrid work than FAH lately.
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Message 53967 - Posted: 21 Mar 2020 | 22:16:39 UTC

Regarding BOINC projects: If any doubt left to me about Rosetta@home implication in COVID-19 research... Now it's solved. com'on!


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Message 53968 - Posted: 21 Mar 2020 | 22:59:21 UTC - in response to Message 53966.

If you were following the greatest BOINC team site in the world, which everyone should be ;) you'd know that all you need to do is set exclusions in cc_config for FahCore_21.exe and 22. This works for GPU, which is all that I'm doing.

<exclusive_app>FahCore_21.exe</exclusive_app>
<exclusive_app>FahCore_22.exe</exclusive_app>

Set your preferred project to a resource share of zero and you're good to go.

Thanks, but it also suspends all BOINC CPU work. That is too much for me, but it is a clever idea.
Also, for Linux it is just FahCore_21 and FahCore_22, without the ".exe".

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Message 53969 - Posted: 21 Mar 2020 | 23:20:08 UTC

Interesting idea about the Exclusive App!

I'm pretty sure I'd want to use the GPU version though.

https://boinc.berkeley.edu/wiki/Client_configuration

<exclusive_gpu_app>important.exe</exclusive_gpu_app>


I'll think about setting this up, but don't know if it'd work the way I want it to, on my PCs that have 3 GPUs.

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Message 53971 - Posted: 21 Mar 2020 | 23:55:09 UTC - in response to Message 53969.

Interesting idea about the Exclusive App!

I'm pretty sure I'd want to use the GPU version though.

https://boinc.berkeley.edu/wiki/Client_configuration
<exclusive_gpu_app>important.exe</exclusive_gpu_app>


I'll think about setting this up, but don't know if it'd work the way I want it to, on my PCs that have 3 GPUs.

Thanks for pointing this parameter out, I never noticed it. I've been running separate clients for CPU and GPU for years, and rarely run projects that have GPU work on the CPU, so what I posted works perfectly for me. Actually I run separate clients for every GPU as well so I have better control over what's running. I tend to forget most folks' setups aren't like mine. This <exclusive_gpu_app> is a nice option for mixed work.
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Message 53972 - Posted: 22 Mar 2020 | 0:29:57 UTC - in response to Message 53960.

One possible solution:

This is a low level heavily scripted option but might make a useful project if you have time or the inclination.

Step 1
Use nvidia-smi to check for low GPU temperature....eg less than 12W. This will indicate no activity in Folding@home.(nvidia-smi can output selected figures such as power, I have used this in the past)

Step 2
On low temp use boinccmd to set gpugrid as active and retrieve a wu.

Step 3
pause 300 seconds, then use boinccmd to set gpugrid status: fetch no more tasks

Step 4
use either boinccmd or nvidia-smi to check for activity in gpugrid. When gpugrid task complete, fetch folding@home task. Havent scripted folding@home so cant comment on commandline control of fetching tasks there.(this could render this script pointless)

Step 5
repeat

I can submit a script when free in a day or so if needed.

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Message 53973 - Posted: 22 Mar 2020 | 0:50:00 UTC

It looked to me like FAH is accessed via telnet, which might be a pain. Haven't fully researched it all. Also, I'm attached to all 55 projects, with GPU work allowed for about 5 some of which also have CPU work I want, so I'm not interested in suspending projects :)

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Message 53975 - Posted: 22 Mar 2020 | 15:26:06 UTC - in response to Message 53923.

I am planning SARS-CoV-2 work.

When will this work be available?

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Message 53977 - Posted: 22 Mar 2020 | 17:24:24 UTC

I just got a long run marked PABLO. Is this COVID-19 research?

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Message 53981 - Posted: 22 Mar 2020 | 18:52:32 UTC - in response to Message 53977.

I just got a long run marked PABLO. Is this COVID-19 research?

Never mind- it errored out after 4 seconds.

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Message 53983 - Posted: 22 Mar 2020 | 19:37:20 UTC - in response to Message 53981.

I just got a long run marked PABLO. Is this COVID-19 research?

Never mind- it errored out after 4 seconds.

Probably a virus...

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Message 53989 - Posted: 22 Mar 2020 | 21:49:44 UTC - in response to Message 53983.
Last modified: 22 Mar 2020 | 21:50:34 UTC

I just got a long run marked PABLO. Is this COVID-19 research?

Never mind- it errored out after 4 seconds.

Probably a virus...


No doubt the OC@2GHz virus. ๐Ÿž๐Ÿ’ป๐Ÿž

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Message 53990 - Posted: 22 Mar 2020 | 22:10:09 UTC - in response to Message 53958.

The real conundrum is the preparedness of the public health services and/or governments which is put to the test by this world wide pandemic.

Here, in Italy, the situation is dramatic

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Message 53991 - Posted: 22 Mar 2020 | 22:51:11 UTC - in response to Message 53990.

Here, in Italy, the situation is dramatic

You have probably heard of remdesivir.
https://www.npr.org/sections/health-shots/2020/03/21/819099156/might-the-experimental-drug-remdesivir-work-against-covid-19

It was used on an elderly patient in Italy with apparent success, though the trials are ongoing.

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Message 53996 - Posted: 23 Mar 2020 | 5:46:14 UTC - in response to Message 53981.

I just got a long run marked PABLO. Is this COVID-19 research?

Never mind- it errored out after 4 seconds.


Interesting, 64 tasks released without Wrapper (using ACEMD2 v9.23 Windows). Did someone forget to use ACEMD3?

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Message 54035 - Posted: 24 Mar 2020 | 22:48:04 UTC - in response to Message 53996.

Interesting, 64 tasks released without Wrapper (using ACEMD2 v9.23 Windows). Did someone forget to use ACEMD3?

Please tell this old newbie how you knew that, I'd be much obliged.

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Message 54039 - Posted: 25 Mar 2020 | 0:01:40 UTC - in response to Message 54035.
Last modified: 25 Mar 2020 | 0:11:41 UTC

Interesting, 64 tasks released without Wrapper (using ACEMD2 v9.23 Windows). Did someone forget to use ACEMD3?

Please tell this old newbie how you knew that, I'd be much obliged.


Last year in April, GPUgrid embarked on an upgrade of their WUs so they would be compatible with CUDA 10 and Turing based GPUs. The new design of the WUs used "Wrappers" to make the WUs more portable and easier to create for the Project team.
The last of the old WUs issued by GPUgrid were ACEMD2 with a version number of v9.xx
The release of the new WUs was in October last year. The new WUs have been referred to as ACEMD3 with a version number of 2.xx

For your reference, the list of GPUgrid apps are found here:
http://www.gpugrid.net/apps.php

If you check the Server Status page you can see "Short ..." and "Long ..." WUs. These are the legacy ACEMD2 WUs that wont run on Turing based GPUs and havent been issued since October last year (Windows only).

We are currently running WUs listed as "New Version of ACEMD".

At the bottom of the Server Status page you can see a detailed list of the ACEMD2 WUs which lists the current batch of "old" WUs.

All have failed.

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Message 54064 - Posted: 25 Mar 2020 | 16:19:48 UTC - in response to Message 54039.

Thanks very much Rod4X4! I seem to have a lot of catching up to do on history here. I really appreciate the mentoring.

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Message 54073 - Posted: 25 Mar 2020 | 23:23:26 UTC - in response to Message 54064.

Thanks very much Rod4X4! I seem to have a lot of catching up to do on history here. I really appreciate the mentoring.


Your welcome

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Message 54287 - Posted: 10 Apr 2020 | 21:19:58 UTC
Last modified: 10 Apr 2020 | 21:30:15 UTC

Is the FAHClient_22 use CUDA?
I coulndn't find a clear answer for that on their forum. (It is planned as far I could find anything about it.)
I get power consumption with that app as much I get with acemd3.
I've never experienced that an OpenCL app could draw as much power as a CUDA app does.
Is there a way to force work assignment besides restarting the FAHClient service? (like pushing the "update" button in BOINC manager.)
It is very hard to get any work from FAH...

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Message 54288 - Posted: 10 Apr 2020 | 22:19:19 UTC
Last modified: 10 Apr 2020 | 22:20:51 UTC

Good questions! I don't have the answers though, sorry.

Regarding getting work in F@H... Whenever it gets stuck and isn't getting work, I have been using FAHControl (the Advanced Control program), to tell the PC or slot(s) to Pause, then tell the PC or slot(s) to Fold. I think this resets backoff timers, and might even allow it to hit different servers when trying to find work.

Regarding keeping the GPUs busy when F@H it out of work... I have setup my PCs with a BOINC GPU Exclusion for FahCore_22.exe .... so that, if none of the GPUs in the PC are working on F@H GPU tasks, it will at least allow BOINC to put those GPUs to work on BOINC projects.

.. in cc_config.xml ..

<exclusive_gpu_app>FahCore_22.exe</exclusive_gpu_app>


I'm not an expert, and I don't even know if this is the best approach towards keeping my PC GPUs busy (especially when 2 of my PCs have 3 GPUs in them, and I want all 3 to be crunching!)

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Message 54289 - Posted: 10 Apr 2020 | 22:55:40 UTC - in response to Message 54287.

Is the FAHClient_22 use CUDA?

No, it doesn't yet. But they plan for it.

And curious you should ask. I am in a rather fraught discussion of that now.
Maybe you can enlighten some of them on the benefits better than I can.
https://foldingforum.org/viewtopic.php?f=17&t=34173&p=324695#p324695

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Message 54304 - Posted: 11 Apr 2020 | 22:30:57 UTC
Last modified: 11 Apr 2020 | 22:43:46 UTC

I haven't been to F@h for a couple of years. DartMouse wrote a series of Linux scripts to deal the various bugs. He hasn't earned CURE in over a year. I don't know what they do or how they work. I merely offer them for your perusal, caveat utilitor:

https://drive.google.com/drive/folders/1Vvckgu5SK_hVM7NlCfCXZDDs2vaVI99o

P.S., I would think that this monthly chart would convince Chodera et alia that they need to change their ways, guess not:
https://folding.extremeoverclocking.com/team_summary.php?s=&t=224497

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Message 54318 - Posted: 14 Apr 2020 | 4:18:13 UTC - in response to Message 54304.

...
P.S., I would think that this monthly chart would convince Chodera et alia that they need to change their ways, guess not:
https://folding.extremeoverclocking.com/team_summary.php?s=&t=224497

I would guess the massive decline in CureCoin's value is mostly responsible for that. There's certainly not a decline in total compute power at present.

The recent influx of users has brought with it a lot of developer interest in the project, hopefully they can take advantage of that and fix bugs plus improve performance.
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Join us and #crunchforcures. We are now also folding:join team ID 236370!

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Message 54319 - Posted: 14 Apr 2020 | 13:47:42 UTC

on theregister.co.uk there is a notice saying that Folding@home has broken the exaflops barrier and is now the fastest computer on the Earth. Is this possible?
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Message 54320 - Posted: 14 Apr 2020 | 15:00:25 UTC - in response to Message 54319.

on theregister.co.uk there is a notice saying that Folding@home has broken the exaflops barrier and is now the fastest computer on the Earth. Is this possible?
Tullio


It is possible, that according to their benchmarks the connected hosts computing power reached that level. However I couldn't get a single workunit for 1,5 week before I abandoned it, so many GPU can be counted towards computing power without getting a hold onto a work unit.

Of course I do not know, how they exactly measure computing power, but after the announcement of Nvidia, and the joining of many Seti guys, a single user with a somewhat outdated GPU (Rx480) I really felt useless there. Now I upgradet to 2070 OC, but never tried the app again. It was really annoying to pause-start-pause-start to reset the counter, just to see, there aren't any WUs.

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Message 54322 - Posted: 14 Apr 2020 | 19:58:15 UTC
Last modified: 14 Apr 2020 | 20:01:45 UTC

I have been running SETi and using GPUGRID as my backup project for quite some time.

Since the demise of SETI I have been running GPUGRID for my GPUs and rosetta on my CPUs and all has been fine. I have been running 2 WUs (one each) on my 2 nvidia 1070s and 9 wus on my 12 CPU AMD computer (leaving 1 CPU and 12 Logical CPUs idle). That gave me 2 GPUs busy and 2 WUs "in the wings" ready to run. BOINC 7.14.2 Win-10.

BUT

Since the introduction of ACEMD 2.10 I am only running 1 WU (on GPU 0) nothing on GPU 1 and 3 WUs "in the wings".

I have plenty of memory (32Gb total) plenty of page file (64Gb) and plenty of free disk space (232Gb) as well as "13 process slots". I have scheduled 4.5 days of work plus .1 day of "additional' work".

As far as I know the only thing to change is the move to V2.10 .

any ideas on where to look to get both GPUs running would be appreciated

Ed Frybarger

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Message 54323 - Posted: 14 Apr 2020 | 20:10:46 UTC - in response to Message 53932.

That is how I am rolling

CPU to rosetta, and GPU to GPUGRID. seems to be working well. rosetta is very memory hungry, eats pretty much all my 16GB

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Message 54324 - Posted: 14 Apr 2020 | 20:16:53 UTC - in response to Message 54322.

[quote

any ideas on where to look to get both GPUs running would be appreciated

Ed Frybarger[/quote]

What flavor of linux are you running on the Dual Nvidia GTX 1070's system.

I am running Ubuntu 18.04 (for now), with dual Nvidia GTX 1070 ti's. Both running well.

You are also running an old Nvidia Driver (390), I recommending upgrading your driver.

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Message 54325 - Posted: 14 Apr 2020 | 21:06:33 UTC - in response to Message 54322.

For the Linux hosts and the 2.10 app, the minimum driver level is 410 for the 1070's.
https://www.gpugrid.net/forum_thread.php?id=5002&nowrap=true#53704

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Message 54326 - Posted: 14 Apr 2020 | 21:14:05 UTC - in response to Message 54324.

running win-10 with most current nvidia driver 445.75.

BOINC is set to use 100% memory and 75% page/swap space.

also ...

GPUGRID will run 2 NVIDIA GPU's (0 and 1) IFF I suspend rosetta. (now there's a twist ... some sort of memory shortage?? I shut rosetta down to 4 cpu's and it didn't change the GPUGRID problem at all)

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Message 54327 - Posted: 14 Apr 2020 | 21:14:10 UTC - in response to Message 54324.
Last modified: 14 Apr 2020 | 21:15:24 UTC

oops double post

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Message 54328 - Posted: 14 Apr 2020 | 22:02:49 UTC
Last modified: 14 Apr 2020 | 22:11:03 UTC

Would you please consider discussing non-Folding@home stuff in a new thread? Thanks.

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Message 54329 - Posted: 14 Apr 2020 | 22:15:09 UTC - in response to Message 54320.

so many GPU can be counted towards computing power without getting a hold onto a work unit.

That's not how it works. Like with BOINC, the processing power estimate is based on actual returned work, not registered hardware in the system. So yes, they did break that barrier and if they managed to get enough servers up to completely saturate every connected host, it should be considerably higher still. See https://stats.foldingathome.org/os

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Message 54335 - Posted: 15 Apr 2020 | 11:58:39 UTC - in response to Message 54287.

I've never experienced that an OpenCL app could draw as much power as a CUDA app does.

It's true only if you use Nvidia gpu...

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Message 54337 - Posted: 15 Apr 2020 | 15:23:16 UTC

Ed, You may need to add this line to your cc_config.xml file:

<use_all_gpus>1</use_all_gpus>

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Message 54456 - Posted: 27 Apr 2020 | 18:39:19 UTC

Where can I find information on Folding@home resource usage in BOINC terms? For example, how many virtual CPU cores does it use? Does this vary with the Folding@home Power setting?

So far, it seems that running both BOINC and Folding@home at the same time slows down the BOINC work quite a bit, due to the number of background processes being much more than the number of virtual cores.

So far, I'm only running CPU work for Folding@home, and plan to continue this until they have a steady enough supply of GPU WUs that there will be little variation in the fan noise from my computer.

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Message 54457 - Posted: 27 Apr 2020 | 19:45:08 UTC - in response to Message 54456.
Last modified: 27 Apr 2020 | 19:58:50 UTC

For example, how many virtual CPU cores does it use? Does this vary with the Folding@home Power setting?
Yes. Moreover you can configure it manually if you select Configure -> Slots tab -> CPU -> Edit -> set/select the number of CPU threads.
It shouldn't be a prime number, except for 2 and 3 (so it shouldn't be 5, 7, 11, 13, 17, 19, 23 etc. Fahcore will reduce the number of its threads by 1 if you set one of the forbidden numbers.)

So far, I'm only running CPU work for Folding@home, and plan to continue this until they have a steady enough supply of GPU WUs that there will be little variation in the fan noise from my computer.
You can set up BOINC to stop GPU work when the FahCore_22.exe is running by adding it to the exclusive GPU apps (lower pane) in the options menu.
FahCore_22.exe is located at
%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

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Message 54458 - Posted: 27 Apr 2020 | 19:54:03 UTC - in response to Message 54335.
Last modified: 27 Apr 2020 | 19:57:15 UTC

I've never experienced that an OpenCL app could draw as much power as a CUDA app does.

It's true only if you use Nvidia gpu...

It's obvious. If I used other GPU, I couldn't run a CUDA app at all, so my comparison couldn't be done.

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Message 54460 - Posted: 27 Apr 2020 | 20:50:54 UTC

Is there any config available for Folding@home to enable a Turing card?

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Message 54461 - Posted: 27 Apr 2020 | 21:29:56 UTC - in response to Message 54460.
Last modified: 27 Apr 2020 | 21:53:26 UTC

Is there any config available for Folding@home to enable a Turing card?

I am running both a GTX 1660 Ti and an RTX 2060 on Folding (Ubuntu 18.04.4). No special configuration is necessary, just a recent driver.

PS - On Ubuntu, you have to install the OpenCL driver. It is not included in the Nvidia driver. That isn't necessary for Windows of course (unless it is).
sudo apt install ocl-icd-opencl-dev

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Message 54463 - Posted: 27 Apr 2020 | 23:44:16 UTC - in response to Message 54460.
Last modified: 27 Apr 2020 | 23:46:00 UTC

Is there any config available for Folding@home to enable a Turing card?
I couldn't add the GPU though the graphical user interface with the v7.6.9, as it always gave number -1 for the GPU slot.
So I edited the %AppData%\FAHClient\config.xml file, I added the following line:
<slot id='1' type='GPU'/>
before the last line:
</config>
Now it works.

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Message 54464 - Posted: 28 Apr 2020 | 0:24:48 UTC - in response to Message 54463.

Thanks! This worked.

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Message 54465 - Posted: 28 Apr 2020 | 1:01:24 UTC - in response to Message 54457.

Retvari Zoltan,

I set the virtual core limit for Folding @home as you suggested. However, the change has not taken effect yet. I suspect that it won't before the next CPU WU starts.


%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

No such file for me. However, I did find this file and tried it instead, assuming that I interpreted %AppData% correctly:

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\avx\Core_22.fah\FahCore_22.exe

This disabled BOINC use of the GPU if a Folding@home CPU task was running, so I doubt if that was correct.

Incidentally, I doubt if my CPU has the AVX feature.

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Message 54470 - Posted: 28 Apr 2020 | 8:55:26 UTC - in response to Message 54465.
Last modified: 28 Apr 2020 | 9:28:15 UTC

I set the virtual core limit for Folding @home as you suggested. However, the change has not taken effect yet. I suspect that it won't before the next CPU WU starts.
It should take effect immediately, however I had to do it twice, carefully clicking on "OK" and "SAVE".

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

No such file for me.
Perhaps your host haven't downloaded any GPU workunit yet.

However, I did find this file and tried it instead, assuming that I interpreted %AppData% correctly:

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\avx\Core_22.fah\FahCore_22.exe
That's strange, there should be the CPU app in the avx folder, which is Core_a7.fah\FahCore_a7.exe.
%AppData% should point to the current user's AppData\Roaming directory, similar to:
C:\Users\Your username\AppData\Roaming
so the whole path should look like:
C:\Users\Your username\AppData\Roaming\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

This disabled BOINC use of the GPU if a Folding@home CPU task was running, so I doubt if that was correct.
You are right, it's the CPU application.
Are you sure you put it in the lower pane?

Incidentally, I doubt if my CPU has the AVX feature.
If it's the i7-5960X, it has SSE4.2 and AVX2. (It's a Haswell-E).

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Message 54478 - Posted: 28 Apr 2020 | 11:37:47 UTC - in response to Message 54463.

I couldn't add the GPU though the graphical user interface with the v7.6.9, as it always gave number -1 for the GPU slot.
So I edited the %AppData%\FAHClient\config.xml file, I added the following line:
<slot id='1' type='GPU'/>
before the last line:
</config>
Now it works.

Good point. I have complained about that more than once on the Folding forum.

Another method is just to set the "opencl-index" to "0", which works for my Nvidia cards on Ubuntu. It may depend on the card/motherboard/OS combination, but the automatic setting never works for me on Ubuntu. Maybe it works on Windows, at least for AMD cards

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Message 54479 - Posted: 28 Apr 2020 | 13:25:18 UTC - in response to Message 54470.

I set the virtual core limit for Folding @home as you suggested. However, the change has not taken effect yet. I suspect that it won't before the next CPU WU starts.
It should take effect immediately, however I had to do it twice, carefully clicking on "OK" and "SAVE".

I tried again, with that change, and this time it took effect immediately. However, it appeared to take the number as meaning real CPU cores, instead of virtual CPU cores. Trying again with half of that number also worked immediately, but appeared to leave an extra fraction of a virtual core in use.

Reducing the virtual core count for BOINC by 1 appears to have stopped the CPU contention.

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

No such file for me.
Perhaps your host haven't downloaded any GPU workunit yet.

As far as I can tell, it hasn't.

However, I did find this file and tried it instead, assuming that I interpreted %AppData% correctly:

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\avx\Core_22.fah\FahCore_22.exe
That's strange, there should be the CPU app in the avx folder, which is Core_a7.fah\FahCore_a7.exe.
%AppData% should point to the current user's AppData\Roaming directory, similar to:
C:\Users\Your username\AppData\Roaming
so the whole path should look like:
C:\Users\Your username\AppData\Roaming\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\Core_22.fah\FahCore_22.exe

Correction - what I found was actually:

%AppData%\FAHClient\cores\cores.foldingathome.org\v7\win\64bit\avx\Core_a7.fah\FahCore_a7.exe

This disabled BOINC use of the GPU if a Folding@home CPU task was running, so I doubt if that was correct.
You are right, it's the CPU application.
Are you sure you put it in the lower pane?

I did - but as you said, it was the wrong file.

Incidentally, I doubt if my CPU has the AVX feature.
If it's the i7-5960X, it has SSE4.2 and AVX2. (It's a Haswell-E).

It is. It now looks like the way I was looking for the AVX feature listing put it off the edge of the screen.

My first Folding@home WU appears to have run with AVX and successfully, but all WUs since that one appear to have run with SSE2 instead, also successfully.

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Message 54480 - Posted: 28 Apr 2020 | 13:54:28 UTC - in response to Message 54478.
Last modified: 28 Apr 2020 | 14:01:19 UTC

I couldn't add the GPU though the graphical user interface with the v7.6.9, as it always gave number -1 for the GPU slot.
So I edited the %AppData%\FAHClient\config.xml file, I added the following line:
<slot id='1' type='GPU'/>
before the last line:
</config>
Now it works.

Good point. I have complained about that more than once on the Folding forum.

Another method is just to set the "opencl-index" to "0", which works for my Nvidia cards on Ubuntu. It may depend on the card/motherboard/OS combination, but the automatic setting never works for me on Ubuntu. Maybe it works on Windows, at least for AMD cards

Under Windows 10 with an Intel CPU, it did not even create a GPU slot for my Nvidia GPU.

My attempts to log in to the Folding forum have always failed, so I haven't been able to complain there yet.

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Message 54482 - Posted: 28 Apr 2020 | 15:43:50 UTC - in response to Message 54480.

Under Windows 10 with an Intel CPU, it did not even create a GPU slot for my Nvidia GPU.

My attempts to log in to the Folding forum have always failed, so I haven't been able to complain there yet.

I will save you the trouble.
https://foldingforum.org/viewtopic.php?f=108&t=34873

One of their endearing curiosities is that you have to download a "GPUs.txt" file to recognize a card. It should happen automatically, but may take a reboot or downloading it separately.

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Message 54484 - Posted: 28 Apr 2020 | 17:09:36 UTC - in response to Message 54482.

Under Windows 10 with an Intel CPU, it did not even create a GPU slot for my Nvidia GPU.

My attempts to log in to the Folding forum have always failed, so I haven't been able to complain there yet.

I will save you the trouble.
https://foldingforum.org/viewtopic.php?f=108&t=34873

One of their endearing curiosities is that you have to download a "GPUs.txt" file to recognize a card. It should happen automatically, but may take a reboot or downloading it separately.

Thanks. I am currently running BOINC set not to download any GPU tasks in order to avoid a GPU conflict during the change.

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Message 54486 - Posted: 28 Apr 2020 | 21:00:43 UTC - in response to Message 54484.

[snip]

I will save you the trouble.
https://foldingforum.org/viewtopic.php?f=108&t=34873

One of their endearing curiosities is that you have to download a "GPUs.txt" file to recognize a card. It should happen automatically, but may take a reboot or downloading it separately.

Thanks. I am currently running BOINC set not to download any GPU tasks in order to avoid a GPU conflict during the change.

All BOINC GPU tasks now finished. I manually downloaded GPUs.txt, but it went onto the Pictures folder instead of the Downloads folder.

Copying it to FAHClient and rebooting allowed me to create a GPU slot, once I recognized the circle to the left of the GPU section as a place to click.

It's now Paused; waiting for idle.

How do I supply the idle?

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Message 54487 - Posted: 28 Apr 2020 | 21:11:18 UTC - in response to Message 54486.
Last modified: 28 Apr 2020 | 21:15:19 UTC

Idle slots in Folding@Home are quite normal right now. I think they are still swamped, and still routinely see some idle slots. They have their own mechanism to ask for work and keep asking at certain times. You might be able to reset the timers by pausing idle slots, and then unpausing them.

https://foldingathome.org/start-folding/

Please be patient if you experience idle time as we face the COVID-19 pandemic together! We are working like mad to start simulations of COVID-19 proteins. The enthusiastic response to our effort has been tremendous and has sometimes emptied our queues. This is a great โ€œproblemโ€ to have as there is no end to the valuable science we can do, its just a matter of giving us some time to get more running.


https://www.facebook.com/permalink.php?story_fbid=2995627323837798&id=136059519794607&substory_index=0

It is for this reason -- slots idle -- that I set Folding@Home CPU to just use 1 CPU thread on each of my PCs, and then have BOINC use my other CPUs/threads. And I have a BOINC GPU "Exclusive Application" set for FahCore_22.exe ... so that *if* Folding@Home is using the GPU, BOINC won't, but if Folding@Home isn't using the GPU, BOINC will.

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Message 54489 - Posted: 29 Apr 2020 | 0:39:49 UTC - in response to Message 54487.
Last modified: 29 Apr 2020 | 0:40:19 UTC

It is for this reason -- slots idle -- that I set Folding@Home CPU to just use 1 CPU thread on each of my PCs, and then have BOINC use my other CPUs/threads.

They seem to be separating the CPU work units into large and small now, with n<9 being the dividing line from what I can discern.

There is apparently more work for the "large" ones; my Ryzen 3950X running 31 out of 32 virtual cores has been busy almost all the time for the last week. On the other hand, when I ran my i7-9700 (8 full cores), it was out of work so often that I took it down. The situation is fluid, so YMMV, but if you have a large number of cores to throw at it, it could work.

By the way, to my surprise, I am averaging around 500k PPD on the Core A7 CPU work; that is up in GPU territory (Ubuntu 18.04.4).

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Message 54490 - Posted: 29 Apr 2020 | 3:07:23 UTC - in response to Message 54487.

[snip]

It is for this reason -- slots idle -- that I set Folding@Home CPU to just use 1 CPU thread on each of my PCs, and then have BOINC use my other CPUs/threads. And I have a BOINC GPU "Exclusive Application" set for FahCore_22.exe ... so that *if* Folding@Home is using the GPU, BOINC won't, but if Folding@Home isn't using the GPU, BOINC will.

That's close to what I'm aiming for, but it doesn't look like I'll be able to finish the setup until my computer downloads at least one GPU WU.

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Message 54494 - Posted: 29 Apr 2020 | 15:10:21 UTC - in response to Message 54489.
Last modified: 29 Apr 2020 | 15:11:07 UTC

They seem to be separating the CPU work units into large and small now, with n<9 being the dividing line from what I can discern.

There is apparently more work for the "large" ones; my Ryzen 3950X running 31 out of 32 virtual cores has been busy almost all the time for the last week.
31 is a prime number, so your CPU app most probably runs only on 30 threads. (check the log at the point when the CPU app started.)
BTW I doubt that there's much benefit above ~20 threads on a 16 core CPU.

On the other hand, when I ran my i7-9700 (8 full cores), it was out of work so often that I took it down. The situation is fluid, so YMMV, but if you have a large number of cores to throw at it, it could work.
Usually I have CPU work on my i7-9700F (6 cores for FAH) and i5-8500 (4 cores for FAH).

By the way, to my surprise, I am averaging around 500k PPD on the Core A7 CPU work; that is up in GPU territory (Ubuntu 18.04.4).
I doubt that. You should check the PPD when there's only CPU work on your host.

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Message 54511 - Posted: 1 May 2020 | 10:22:23 UTC

To my surprise I received some FahCore 21 tasks lately, so it is recommended to add FahCore_21.exe (FahCore_21 on Linux) to the exclusive GPU app list.

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Message 54512 - Posted: 1 May 2020 | 10:25:17 UTC

Yep, I just had to do the same! :)

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Message 54515 - Posted: 1 May 2020 | 14:34:03 UTC - in response to Message 54511.

To my surprise I received some FahCore 21 tasks lately, so it is recommended to add FahCore_21.exe (FahCore_21 on Linux) to the exclusive GPU app list.

I'm still waiting for one. BOINC doesn't seen to have a way to add it to the exclusive GPU app list before the file is downloaded.

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Message 54516 - Posted: 1 May 2020 | 15:38:32 UTC - in response to Message 54515.

You can always close BOINC, then add these lines to your cc_config.xml file, in the <options> section:

<exclusive_gpu_app>FahCore_21.exe</exclusive_gpu_app>
<exclusive_gpu_app>FahCore_22.exe</exclusive_gpu_app>


Full documentation on the options you can set, is here:
https://boinc.berkeley.edu/wiki/Client_configuration

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Message 54518 - Posted: 1 May 2020 | 17:11:13 UTC - in response to Message 54516.

You can always close BOINC, then add these lines to your cc_config.xml file, in the <options> section:

<exclusive_gpu_app>FahCore_21.exe</exclusive_gpu_app>
<exclusive_gpu_app>FahCore_22.exe</exclusive_gpu_app>


Full documentation on the options you can set, is here:
https://boinc.berkeley.edu/wiki/Client_configuration

Thank you. I just made that change.

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Message 54519 - Posted: 1 May 2020 | 18:25:26 UTC

The CPU app (FahCore_a7) is the toughest I've ever run.
I had to decrease the overclocking of my old i7-4770K from 4GHz cores + 4GHz uncore to 3.7GHz cores + 3.5GHz uncore to reduce heat output (decreasing voltages as well) and to avoid abrupt restarts / lockups on that host.
There is much variation in the power consumption of the CPU between workunits.
Roughly saying the higher the credit, the higher the power it uses.

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Message 54726 - Posted: 17 May 2020 | 18:15:06 UTC

There is another interesting project about Covid-19: https://boinc.ibercivis.es/ibercivis/ from hard hit Spain.

There goal is to investigate, if some of the known viral medication might work as well on Covid-19.

They might need some love.

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Message 54728 - Posted: 17 May 2020 | 20:07:14 UTC

World Community Grid now has their Open Pandemics subproject running, With COVID-19 as the first pandemic it is working on.

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Message 54731 - Posted: 17 May 2020 | 22:11:24 UTC

Nice!

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Message 54732 - Posted: 17 May 2020 | 23:14:44 UTC - in response to Message 54519.

The increase in power is likely that Fahcore_a7 is utilizing AVX set instructions.

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Message 54733 - Posted: 18 May 2020 | 0:16:25 UTC - in response to Message 54732.

The increase in power is likely that Fahcore_a7 is utilizing AVX set instructions.


I concur. This is most likely.

You should implement an AVX offset in your BIOS if your motherboard has that feature. It will reduce the clocks when it detects AVX workloads.
____________

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Message 56325 - Posted: 26 Jan 2021 | 23:51:32 UTC
Last modified: 26 Jan 2021 | 23:57:04 UTC

The MMR vaccine offer some protection against COVID-19.

Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients

https://mbio.asm.org/content/11/6/e02628-20

Do you have enough information on mumps antibodies that you could create workunits to dock them to parts of the virus?

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Message 56327 - Posted: 29 Jan 2021 | 14:30:04 UTC - in response to Message 56325.
Last modified: 29 Jan 2021 | 14:31:12 UTC

Respectfully, you are misunderstanding the finding:

"Our results demonstrate that there is a significant inverse correlation between mumps titers from MMR II and COVID-19 severity."

That does not mean that the MMR vaccine can prevent COVID-19. It means that a statistical association was observed. Correlation is not causation.

Persons without medical contraindications are advised to be immunized with MMR (measles-mumps-rubella) vaccine because measles is a serious disease potentially fatal to children, it is perhaps the most transmissible virus known to man, and there was multi-year global outbreak prior to COVID-19. But not because the MMR vaccine has been proven to prevent COVID-19.

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Message 56331 - Posted: 30 Jan 2021 | 23:07:57 UTC

Hmmm... I hate to be a party pooper, but:
My personal opinion is that crunching for COVID-19 is not very useful.
The whole world is looking for drugs to fight that disease, and they are doing thousands of in vitro tests a day, which works a lot quicker than computer simulations.

So my humble opinion is this: (I may be wrong)
It is better to let our computers crunch data for diseases which either do not receive enough attention (child cancer, Tuberculosis, ...) or diseases of which we know that a lot of work is needed for years/decades to come like cancer, so long term projects.

So if GPUGRID stays without WUs for some more time and I decide to temporarily switch to Folding@Home - at least for my GPUs - I would rather let them do work for Cancer for example, rather than COVID-19.
We have vaccines for COVID-19 now, but a lot of work remains to be done before we can beat cancer definitively, or child cancer, or tuberculosis etc.

My CPUs do work for the Mapping Cancer Markers project, the tuberculosis project and the Child Cancer project at World Community Grid.
Alas these do not use GPUs.
So if you want to put your GPUs to work, I would choose diseases at Folding@Home which will need long term work (years/decades) before we can beat them.
Something like Covid-19 which is already being beaten by the first generation of vaccines... I just think it is less interesting for our species to put our GPUs to work on something which is about to get solved by the first vaccine generation, at least temporarily.

This is just my opinion.
But I respect everybody's choice of course. Use your GPUs the way you like. :-)
My choice is to put my GPUs to work on longer-term problems.

Greetings, and have a nice day;
Carl

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Message 56332 - Posted: 30 Jan 2021 | 23:57:43 UTC - in response to Message 56331.
Last modified: 30 Jan 2021 | 23:58:36 UTC

Hmmm... I hate to be a party pooper, but:
My personal opinion is that crunching for COVID-19 is not very useful.
The whole world is looking for drugs to fight that disease, and they are doing thousands of in vitro tests a day, which works a lot quicker than computer simulations.

I think there is considerable merit to that, and have been wondering about it myself (with over 100 Ryzen 3000 virtual cores on WCG/OPN at the moment). The limiting factor at the moment is testing, with animal testing and then human testing being even more limited and expensive than in vitro testing.

However, there is the question of mutations. We need something that targets a broad range of viruses, and it might be possible that the computer simulations can do that. In particular, I think that Folding can find and target areas of the virus that the ordinary testing techniques will miss. I have 10M PPD riding on it in any case. I hope something works.

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Message 56333 - Posted: 31 Jan 2021 | 0:58:55 UTC - in response to Message 56332.

Hmmm... I hate to be a party pooper, but:
My personal opinion is that crunching for COVID-19 is not very useful.
The whole world is looking for drugs to fight that disease, and they are doing thousands of in vitro tests a day, which works a lot quicker than computer simulations.

I think there is considerable merit to that, and have been wondering about it myself (with over 100 Ryzen 3000 virtual cores on WCG/OPN at the moment). The limiting factor at the moment is testing, with animal testing and then human testing being even more limited and expensive than in vitro testing.

However, there is the question of mutations. We need something that targets a broad range of viruses, and it might be possible that the computer simulations can do that. In particular, I think that Folding can find and target areas of the virus that the ordinary testing techniques will miss. I have 10M PPD riding on it in any case. I hope something works.





Jim, I partially agree with you.
And I did not mean to say that computer simulations are useless against Corona.

But let us not forget that each year, the flu still also kills many people worldwide.
We just have the luxury that we have learned to make quite effective vaccines against the flu each year.
A luxury that we do not have yet against Corona, but the vaccines will get better very quickly: Like the flu, Corona is a rather "simple" virus, nothing compared to the complexity of the HIV virus:
Don't forget that - even after 30 years of research - we have still not found ANY vaccine against HIV. For Corona I took us less than a year to create the first vaccines.

So I do believe that these distributed computing projects about COVID-19 will be quite short-lived:
Compared to the extremely intensive in vitro tests that they are doing now, any computer simulation project is slow:
Computer simulations are a better choice to solve long-term problems like cancer or more advanced viruses like HIV.
The in vitro tests will "solve" Corona rather quickly, by making better and better vaccines just like for the flu.


So I prefer to use my PCs against cancer and HIV for example.
It is just my choice.

I do not have nearly as much computing power as you have. :-)
I recently purchased an AMD Ryzen 9 3900 (non -x) for the Mapping Cancer Markers project at WCG.
That is a 12-core, 24 thread CPU with a TDP of only 65 Watts, so a quite efficient CPU ( OEM only, so a little difficult to find though. )
For the rest, I only have 1 Core i5 8400 6-core/6-thread, and older pcs with 2 AMD A8-9600 quad cores and then an even older Core-2 Duo and a Celeron dual core too.
So compared to your CPU computing power, that is almost nothing. :-)

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Message 56334 - Posted: 31 Jan 2021 | 1:40:33 UTC - in response to Message 56333.

I recently purchased an AMD Ryzen 9 3900 (non -x) for the Mapping Cancer Markers project at WCG.
That is a 12-core, 24 thread CPU with a TDP of only 65 Watts, so a quite efficient CPU ( OEM only, so a little difficult to find though. )

I didn't know there was a non -x version. That looks like good efficiency to me.
There is supposed to be a 5900 non -x version too, but also OEM only. I would love to find one later in the year. I am full for now.

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Message 56335 - Posted: 31 Jan 2021 | 1:52:38 UTC - in response to Message 56331.

Hmmm... I hate to be a party pooper, but:
My personal opinion is that crunching for COVID-19 is not very useful.
The whole world is looking for drugs to fight that disease, and they are doing thousands of in vitro tests a day, which works a lot quicker than computer simulations.

[snip]

You're ignoring the rather high expense of getting new drug candidates made if they have never been produced before.

The computer simulations are much faster and less expensive than getting those new drug candidates made, and are useful in determining which new drug candidates are the most likely to be worth the expense and time required to have them made so that in vitro tests for them become possible.

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Message 56336 - Posted: 31 Jan 2021 | 3:16:45 UTC

Also, while there are many in vitro studies and successes, they often fail at the next stage of animal testing. That is because they kill the virus in the lab, but also kill the animal because they are toxic.

Can the computer studies improve on that success rate? I don't know. We should be finding out before long I would think.

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Message 56337 - Posted: 31 Jan 2021 | 6:51:45 UTC

The lab testing on WCG/OPN should begin shortly.
https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=674

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Message 56338 - Posted: 31 Jan 2021 | 10:23:33 UTC - in response to Message 56334.

I recently purchased an AMD Ryzen 9 3900 (non -x) for the Mapping Cancer Markers project at WCG.
That is a 12-core, 24 thread CPU with a TDP of only 65 Watts, so a quite efficient CPU ( OEM only, so a little difficult to find though. )

I didn't know there was a non -x version. That looks like good efficiency to me.
There is supposed to be a 5900 non -x version too, but also OEM only. I would love to find one later in the year. I am full for now.



fyi:
I found my Ryzen 9 3900 non-x at a site called AWD-IT in the UK.
As it is an OEM chip, they are not allowed to sell it like that,
so they sell it in combination with at least a motherboard.
Apparently for AMD that is "OEM enough". :-)
And you can choose the motherboard.

I was lucky enough to buy mine just before Brexit (I live in Brussels).
But so if you live outside the UK now, I guess customs will be applied.

And if they run out of chips, someone else found one
at a Russian shop called X-Com in Moscow. I saw that if you let your browser translate their site to English , it is quite readable.

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Message 56339 - Posted: 31 Jan 2021 | 17:33:49 UTC - in response to Message 56331.
Last modified: 31 Jan 2021 | 17:37:53 UTC

We have vaccines for COVID-19 now
Those vaccines
1. don't cure those who are actually sick with COVID-19 (ok, some of them does)
2. are hard to produce, store, transport, inject
3. are expensive
So these vaccines are useless for those who live in poverty (for the majority of the world's population).

The aim of the COVID-19 moonshot project (FAH is a main contributor of that with its computing power) is to design a drug which
1. will cure those who are actually sick, or will get sick with COVID-19 (and perhaps many similar corona viruses in the future)
2. are easy to produce, store, transport, take
3. are inexpensive

Don't forget that this corona virus is actually the third (obviously the most successful) one in the last 20 years which threatens our civilization (1st one: SARS; 2nd one: MERS). So brace yourselves, these corona viruses won't let humanity alone in the future. Therefore it is vital that we could develop much better drugs against them much faster than this time if we want to get our everyday lives back, and don't let the world economy collapse (we couldn't support research against cancer and AIDS in this case).

Though Folding@home is now focusing on SARS-COVID-19, it's not only about COVID-19, it has ongoing research about myosins, GPCR, cancer (CPU only), Halorubrum lacusprofundi, Parkinson's, G-proteins.

My main issue with FAH (besides that it's not within BOINC) was that their client (core in their terminology) was openCL (not CUDA). But now it is CUDA, so that's great news for NVidia users like me. My main concern is their set-and-forget approach, so the FAH user interface and cache strategy and web infrastructure is not made to match my tastes. I cannot control my farm through "venues", I can't set cache size, there's no webpage for my hosts to track their workunits etc.

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Message 56340 - Posted: 31 Jan 2021 | 18:18:23 UTC - in response to Message 56339.

My main concern is their set-and-forget approach, so the FAH user interface and cache strategy and web infrastructure is not made to match my tastes. I cannot control my farm through "venues", I can't set cache size, there's no webpage for my hosts to track their workunits etc.

If you use HFM.net, they have a "Tools/Work Unit History Viewer". I don't use it myself and don't know how it compares to BOINC, but it might help. (I have HFM.net installed on a Win10 machine to monitor all my Linux machines over the LAN).

They are stuck with their cache strategy by the type of work they do. They have to start up the next one right away, so can't keep much of a cache. In fact, that is the main reason they don't use BOINC I believe. I have learned to live with their limitations.

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Message 56343 - Posted: 31 Jan 2021 | 21:35:14 UTC - in response to Message 56339.
Last modified: 31 Jan 2021 | 21:48:17 UTC

We have vaccines for COVID-19 now
Those vaccines
1. don't cure those who are actually sick with COVID-19 (ok, some of them does)
2. are hard to produce, store, transport, inject
3. are expensive
So these vaccines are useless for those who live in poverty (for the majority of the world's population).

The aim of the COVID-19 moonshot project (FAH is a main contributor of that with its computing power) is to design a drug which
1. will cure those who are actually sick, or will get sick with COVID-19 (and perhaps many similar corona viruses in the future)
2. are easy to produce, store, transport, take
3. are inexpensive

Don't forget that this corona virus is actually the third (obviously the most successful) one in the last 20 years which threatens our civilization.



You are correct.
Virologists have told us that - had we invested say a billion Dollars in antivirals in the past - we would not be in this situation now.
But we haven't done that because politicians don't want to think about the long term future: They get elected for just 4/5 years, not for 20 years.

But vaccines are not by definition more expensive to make:
Antivirals also need to get an update every year or every x years.
The RNA vaccines like Pfizer's are indeed expensive, hard to store and transport etcetera.
So for Africa for example this vaccine is not a realistic solution.
But Johnson&Johnson has made a vaccine with the developing countries in mind:
It is a lot easier and cheaper to make, and it can be stored for weeks/months in a simple refrigerator. A bit like the flu vaccines actually.
In the EU it will get approval in the coming weeks.
It is less effective in that it has a +-65% chance to keep you from getting sick, but it is equally successful in making sure you don't need to go to a hospital if you do get sick, and that is more important than keeping you from getting sick:
Keep Corona patients out of the hospitals, and keep them from dying.
And this Johnson&Johnson vaccine only needs 1 injection, so that makes it 50% cheaper to transport, store and administer.

I hope we will find antivirals, but will we succeed?
There are many viruses for which we don't have (good) antivirals, because they do also mutate.
HIV is an exception, but as you know they need to keep making new anti-HIV drugs because the virus mutates.
And that makes antivirals also expensive in the long run I guess.

But vaccines might be more expensive because you need to give them to everybody, not just to those who get sick. That is true.

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Message 56344 - Posted: 31 Jan 2021 | 22:38:26 UTC - in response to Message 56343.

But vaccines might be more expensive because you need to give them to everybody, not just to those who get sick. That is true.

The expense should not even be a factor. Whether it is $15 per dose or $150, it is trivial compared to the economic loss. The only factors are speed and efficiency.

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Message 56345 - Posted: 31 Jan 2021 | 22:39:26 UTC

By the way, I wonder about the new drug they gave to Mr. Donald Trump when he got Corona.
It was called "Regeneron" I think.

I wonder how it works:
Is it a simple antiviral molecule, or does it work more like immune therapy, or is it a new generation drug with a patient specific compound...

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Message 56346 - Posted: 31 Jan 2021 | 23:05:39 UTC - in response to Message 56344.

But vaccines might be more expensive because you need to give them to everybody, not just to those who get sick. That is true.

The expense should not even be a factor. Whether it is $15 per dose or $150, it is trivial compared to the economic loss. The only factors are speed and efficiency.




I totally agree:
Once a pandemic has become so big, money should not be the first thing to think about.
That is why I said from the beginning that thanks to the first generation of vaccines, this problem will soon be solved, at least temporarily.
Finding antivirals will take a lot more time, if we find them.

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Message 56347 - Posted: 31 Jan 2021 | 23:46:38 UTC - in response to Message 56346.

But vaccines might be more expensive because you need to give them to everybody, not just to those who get sick. That is true.

The expense should not even be a factor. Whether it is $15 per dose or $150, it is trivial compared to the economic loss. The only factors are speed and efficiency.

I totally agree:
Once a pandemic has become so big, money should not be the first thing to think about.
That is why I said from the beginning that thanks to the first generation of vaccines, this problem will soon be solved, at least temporarily.
Finding antivirals will take a lot more time, if we find them.

Take a look at this map.
Please explain how it is financially viable to vaccinate the population of those countries marked with red color?

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Message 56348 - Posted: 1 Feb 2021 | 1:33:44 UTC - in response to Message 56347.
Last modified: 1 Feb 2021 | 2:00:35 UTC

Please explain how it is financially viable to vaccinate the population of those countries marked with red color?

They will have to wait for the low-cost version. If you force the entire world to wait until a low-cost version is available, you won't have an economy left to do it.

By the way, it is standard practice that most pharmaceutical companies sell their drugs at a lower cost to the third-world countries anyway. They charge the most in the U.S., then Europe, and finally Africa for example. They may be able to offer their vaccines at lower cost first anyway.

EDIT: Europe may lose a year of economic growth in order to bargain Astra-Zeneca and Pfizer down to $15/dose, rather than simply asking them how much they needed to build more production capacity.

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Message 56376 - Posted: 7 Feb 2021 | 9:55:39 UTC - in response to Message 56347.


Please explain how it is financially viable to vaccinate the population of those countries marked with red color?


Or conversely, how is it financially viable not to? The Oxford AstraZenica vaccine is already $3 and there are numerous others in stage 3 trials that will also come in more cheaply (when sold in certain countries). Intuitively, this sounds much cheaper to me than prolonging all these lockdowns (and taking away things like tourism income).

The catchline "we're not safe until everybody is safe" is not just rhetoric. Even small amounts of travel between countries will keep the fire burning and reigniting new waves. Here's a nice (super-simplified) simulation that illustrates:

https://youtu.be/gxAaO2rsdIs?t=775

So it's in even the interests of each country to help the others.

The Covax initiative is a nice start. But of course, rich countries are dragging their heels with their commitments and hoarding for themselves instead (with some buying up well over > 5 doses per citizen!) Politics is a strong factor I guess - they don't want to lose public support, so will pander to their own voters first. This is totally natural of course, but once we start talking 5 doses per person they would actually help even their OWN country more by sending those excess doses abroad!

So I'm very thankful for organizations like the Bill & Melinda Gates foundation that help fill the gap left by political selfishness and corporate greed. They anticipated a pandemic coming, inevitably, and have invested hugely for over 10 years ago, e.g. helping setting up production facilities in India which will be key now in getting upcoming 1-dose vaccines (e.g. Johnson & Johnson and Novavax) out cheaply.

https://www.youtube.com/watch?v=Grv1RJkdyqI

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Message 56377 - Posted: 7 Feb 2021 | 12:02:57 UTC - in response to Message 56347.

In an ideal world the rich world would donate enough vaccine for these very low income countries and maybe they will EVENTUALLY
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Message 56592 - Posted: 17 Feb 2021 | 0:51:47 UTC - in response to Message 56340.

If you use HFM.net, they have a "Tools/Work Unit History Viewer". I don't use it myself and don't know how it compares to BOINC, but it might help. (I have HFM.net installed on a Win10 machine to monitor all my Linux machines over the LAN).
Thanks for that info, that's a really useful tool!
Here's a direct link to it, if someone else is interested downloading it:
https://github.com/harlam357/hfm-net/releases

They are stuck with their cache strategy by the type of work they do. They have to start up the next one right away, so can't keep much of a cache. In fact, that is the main reason they don't use BOINC I believe. I have learned to live with their limitations.
GPUGrid works pretty much the same way, so I'm ok with that caching strategy (I should have the choice to make it download the next wu a bit earlier though), but I still want to track my hosts. I have a failing GTX 1080Ti, which I accidentally noticed, as I couldn't see (until I've installed HFM.net) how many wus failed on that host.

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Message 56861 - Posted: 2 May 2021 | 1:05:14 UTC - in response to Message 53905.

World Community Grid is also offering GPU tasks to work against COVID-19 now.

Select Open Pandemics, and enable GPU use.

https://join.worldcommunitygrid.org?recruiterId=480838

They are currently doing a stress test to see if their servers and internet connections are adequate for this. They use BOINC.

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Message boards : Number crunching : Coronavirus crunching - Folding@home